Purification of bacterial antigens

Details Purification of bacterial antigens Purification of bacterial antigens

C - Chemistry, Metallurgy

07

K

C07K 14/315 (2006.01)

Patent

CA 2642721

Presented are methods of isolation of pili and pilus-like structures from Gram-positive bacteria including Streptococcus pneumoniae and compositions that include such isolated pili. These compositions are useful as immunogenic compositions for the production of antibodies and immunostimulation. Also presented are methods of inhibiting Streptococcus pneumoniae, and methods of identifying inhibitors of Streptococcus pneumoniae.

La présente invention concerne des procédés d'isolement de structures de type pili et pilus issues de bactéries Gram-positives, y compris Streptococcus pneumoniae (pneumocoques), et des compositions qui incluent lesdits pili isolés. Ces compositions sont utiles en tant que compositions immunogènes destinées à la production d'anticorps et à une immuno-stimulation. L'invention concerne en outre des procédés d'inhibition de Streptococcus pneumoniae, et des procédés permettant d'identifier des inhibiteurs de Streptococcus pneumoniae.

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