Purification of gammaglobulin derivative

Details Purification of gammaglobulin derivative Purification of gammaglobulin derivative

A - Human Necessities

61

K

167/139

A61K 39/395 (2006.01) C07K 16/06 (2006.01)

Patent

CA 1128418

PURIFICATION OF GAMMAGLOBULIN DERIVATIVE Abstract of the Disclosure The invention provides a process for the production of a highly purified S-sulfonated gammaglobulin by treating an S-sulfonated gammaglobulin, obtained by sulfonating a conventional gammaglobulin, with an ion exchanger in a buffer solution for development, and thereby absorbing single molecular S-sulfonated gammaglobulin thereon, and then eluting the single molecular S-sulfonated gamma- globulin with a buffer solution for elution. This process can give the desired S-sulfonated gammaglobulin having a high content of single molecules and an extremely small anticomplementary activity (e.g. CH50 of 10% or less) and also an excellent shaking stability from the conventional gammaglobulin on an industrial scale.

341901

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