C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 1/00 (2006.01) A01K 67/027 (2006.01) C07K 14/765 (2006.01) C12N 5/00 (2006.01) C12N 15/63 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2448432
The invention features methods of purifying human serum albumin (hSA) from endogenous serum albumin of the host cell producing the hSA. The methods include providing a sample comprising hSA and serum albumin of the host cell, applying the sample to an affinity column that binds hSA at a higher affinity than the serum albumin of the host cell, eluting bound hSA from the affinity column, and crystallizing the eluted has. The invention also features compositions comprising hSA produced by the methods of the invention.
L'invention concerne des procédés de purification de la sérum-albumine humaine (hSA) à partir de la sérum-albumine endogène de la cellule hôte produisant la hSA. Les procédés consistent à mettre en oeuvre un échantillon renfermant la hSA et la sérum-albumine de la cellule hôte, à appliquer l'échantillon à une colonne d'affinité liant la hSA à une affinité supérieure à celle de la sérum-albumine de la cellule hôte, à éluder la hSA liée de la colonne d'affinité et à cristalliser la hSA éluée. L'invention concerne également des compositions renfermant la hSA produite au moyen des procédés selon l'invention.
Smart & Biggar
Taurus Hsa Llc
LandOfFree
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