Purification of oligodeoxynucleotide phosphorothioates using...

Details Purification of oligodeoxynucleotide phosphorothioates using... Purification of oligodeoxynucleotide phosphorothioates using...

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) C12N 15/10 (2006.01)

Patent

CA 2187338

The present invention provides improved methods for separating and purifying oligonucleotide phosphorothioates. For the first time, we used DMAE ion-exchange chromatography to separate and purify oligonucleotide phosphorothioates. We found that by varying the conditions employed excellent separation can be obtained. In particular, we have been able to use a higher pH and lower salt concentrations than previously reported in the literature to obtain chromatographic separation of oligonucleotide phosphorothionates having length up to about 35 nucleotides.

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