Purification of oligonucleotides

Details Purification of oligonucleotides Purification of oligonucleotides

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) C07H 19/04 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01)

Patent

CA 2398749

Methods and compounds useful for the purification of oligonucleotides and their analogs are provided wherein the oligonucleotides are contaminated with at least one oligonucleotide having at least one abasic site by the formation of imines at the aldehyde moiety of the abasic site and subsequent separation based on extractions, precipitations or chromatography.

L'invention concerne des méthodes et des composés utiles pour la purification d'oligonucléotides ainsi que leurs analogues. Dans cette méthode, ces oligonucléotides sont contaminés avec au moins un oligonucléotide comprenant au moins un site abasique par la formation d'imines sur la fraction aldéhyde du site abasique et leur séparation consécutive sur la base d'extractions, de précipitations ou d'une chromatographie.

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