C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/505 (2006.01) A61K 38/18 (2006.01) A61K 47/48 (2006.01) C07K 1/18 (2006.01)
Patent
CA 2692612
The current invention comprises a method for the purification of mono- PEGylated erythropoietin comprising two cation exchange chromatography steps wherein the same type of cation exchange material is used in both cation exchange chro-matography steps and a method for producing a mono-PEGylated erythropoietin in substantially homogeneous form.
La présente invention concerne un procédé de purification d'érythropoïétine mono-polyéthylène-glycolée. Ce procédé fait intervenir deux étapes de chromatographie d'échange de cations, chaque étape utilisant le même matériau d'échange de cations. L'invention concerne également un procédé de production d'érythropoïétine mono-polyéthylène-glycolée sous une forme sensiblement homogène.
Burg Josef
Reichert Klaus
Schroth Axel
Schurig Hartmut
Wessner Axel
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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