C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/79 (2006.01) C07K 1/14 (2006.01) C07K 14/745 (2006.01) C07K 14/76 (2006.01) C07K 14/765 (2006.01) C07K 14/81 (2006.01)
Patent
CA 2161804
This invention relates to a process for reduction of virus inactivating chemicals and/or detergents in an aqueous composition containing a water-soluble plasma protein. By selecting a suitable combination of temperature and concentration above 0.5 M of a salt with a high salting out effect according to the Hofmeister series, vesicles containing the virus inactivating chemical and/or detergent are formed. These vesicles are removed from the aqueous phase, e.g. by phase separation or filtration, and the protein thereafter isolated from the aqueous phase. The water-soluble plasma protein can be e.g. antithrombin III, transferrin or albumin. When the aqueous phase comprises e.g. a salt of citrate or sulphate in a concentration above 1 M at room temperature, the reduction of virus inactivating chemical or detergent can be as high as 2000 times or more, giving a final concentration below 5 ppm.
Isaksson Sven
Winge Stefan
Fetherstonhaugh & Co.
Kabi Pharmacia Ab
Octapharma Ag
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