C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) C07K 1/36 (2006.01) C07K 14/775 (2006.01) C12N 1/06 (2006.01) C12N 1/21 (2006.01) A61K 43/00 (1990.01)
Patent
CA 2112226
2112226 9300443 PCTABS00019 Applicants describe methods for purifying human ApoE or analog thereof from recombinant bacterial cells with minimal protein aggregation and degradation during the purification process. The invention involves the addition of neutralized fatty acids to the medium during cell disruption and the use of a non-ionic detergent during the purification process. Additionally applicants describe a method for increasing the production of ApoE or analog thereof in a bacterial host by adding to the culture medium neutralized fatty acids, fatty acid precursors, triglycerides, triglyceride precursors or acetate. Pharmaceutical and diagnostic uses of the ApoE analog are described.
Bartfeld Daniel
Fischer Meir
Greenman Benjamin
Lifshitz Ruth
Bio-Technology General Corp.
Gowling Lafleur Henderson Llp
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