Purification of red blood cells by separation and diafiltration

Details Purification of red blood cells by separation and diafiltration Purification of red blood cells by separation and diafiltration

A - Human Necessities

61

K

A61K 38/42 (2006.01) A61K 35/18 (2006.01) A61P 7/08 (2006.01)

Patent

CA 2476177

Red blood cells are purified by separating whole blood, such as by centrifugation, to form a red blood cell fraction and a liquid fraction. The whole blood can be defibrinated or treated to prevent coagulation prior to separation. Preferably, the whole blood is bovine blood. The red blood cell fraction is then diafiltered to purify the red blood cells. The purified red blood cells can then be lysed to form a lysate of purified red blood cells. The purified red blood cells and the lysate of purified red blood cells are suitable for use in producing hemoglobin blood substitute.

L'invention concerne un procédé de purification d'érythrocytes, consistant à séparer du sang total par centrifugation, par exemple, pour obtenir une fraction d'érythrocytes et une fraction liquide. Le sang total peut être défibriné ou traité pour éviter qu'il y ait coagulation avant la séparation. De préférence, le sang total est du sang de bovin. Le procédé consiste ensuite à soumettre la fraction d'érythrocytes à une diafiltration pour purifier les érythrocytes. Les érythrocytes purifiés peuvent ensuite être lysés pour former un lysat d'érythrocytes purifiés. Les érythrocytes purifiés et le lysat d'érythrocytes purifiés peuvent être utilisés pour produire un succédané d'hémoglobine.

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