C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/64 (2006.01) C07K 1/04 (2006.01) C07K 14/00 (2006.01) C07K 14/81 (2006.01) C12N 9/72 (2006.01) C12N 15/10 (2006.01) C12Q 1/37 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2248243
A method is disclosed for obtaining affinity ligands for isolating tissue-type plasminogen activator (tPA). Ligands binding tPA with high specificity at pH 7 and releasing tPA at pH 5 or lower are disclosed. Also disclosed are methods whereby additional ligands having desirable preselected binding and release (elution) characteristics may be isolated, permitting the development of tailored ligands to meet the purification problems presented by any particular feed stream containing tPA.
Cette invention concerne un procédé d'obtention de ligands d'affinité destiné à isoler l'activateur de type tissulaire du plasminogène (tPA). L'invention concerne des ligands qui se lient au tPA avec une grande spécificité à pH 7 et qui libèrent le tPA à un PH inférieur ou égal à 5. L'invention concerne aussi des procédés qui permettent d'isoler d'autres ligands offrant des caractéristiques de liaison et de libération (élution) présélectionnées, et qui permettent le développement de ligands personnalisés destinés à la résolution des problèmes de purification posés par tout courant d'alimentation particulier contenant ledit tPA.
Ladner Robert C.
Maclennan John M.
Ransohoff Thomas C.
Dyax Corporation
Morphosys Ag
Smart & Biggar
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