Purification of vitamin-k dependent proteins by membrane...

Details Purification of vitamin-k dependent proteins by membrane... Purification of vitamin-k dependent proteins by membrane...

C - Chemistry, Metallurgy

12

N

C12N 9/64 (2006.01) C07K 1/16 (2006.01) C07K 14/745 (2006.01) C12N 9/50 (2006.01)

Patent

CA 2178208

Disclosed is a process for preparing agents containing virus-inactivated vitamin K-dependent plasma components as well as protein C, protein S, factors II, VII, IX, and/or X as well as combinations thereof, such as, for example, PPSB preparations, wherein a source containing these components is subjected to appropriate separation procedures, especially by using membrane-chromatographic methods.

Procédé de préparation d'agents renfermant des constituants plasmatiques "vitamine K-dépendants" à inactivation virale ainsi que la protéine C, la protéine S, les facteurs II, VII, IX et/ou X et leurs associations, par exemple les préparations PPSB. Selon le procédé, on soumet une source renfermant ces constituants à des processus appropriés de séparation, notamment à l'aide de procédés de chromatographie sur membrane.

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