Purification of von willebrand factor by cation exchange...

C - Chemistry – Metallurgy – 07 – K

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C07K 14/745 (2006.01) A61K 38/36 (2006.01) A61K 38/37 (2006.01) A61P 7/04 (2006.01) C07K 1/18 (2006.01) C07K 14/755 (2006.01)

Patent

CA 2282843

Disclosed are a method of recovering vWF in which vWF at a low salt concentration is bound to a cation exchanger and vWF having a high specific activity is recovered by fractionated elution, as well as a preparation having purified vWF obtainable by this method.

L'échangeur concerne un procédé permettant d'obtenir un facteur de von Willebrand (vWF), selon lequel un vWF est, avec une faible concentration en sel, lié à un échangeur de cations. On obtient un vWF de forte activité spécifique par élution fractionnée. L'invention concerne également une préparation contenant un vWF purifié pouvant être obtenu par ce procédé.

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