C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/315 (2006.01) A61K 39/09 (2006.01) C07K 1/20 (2006.01) C12P 21/00 (2006.01)
Patent
CA 2518669
The present invention relates to a method for purifying bacterial cytolysins such as pneumococcal pneumolysin. A single chromatography step produces excellent purification of the cytolysin by binding soluble aggregated cytolysin to a hydrophobic interaction chromatography material in the presence of detergent and high salt.
La présente invention porte sur un procédé de purification de cytolysines bactériennes telles que la pneumolysine pneumococcique. Une étape unique de chromatographie permet d'effectuer une excellente purification de la cytolysine en liant la cytolysine soluble agrégée à un matériau chromatographique à interaction hydrophobe en présence de détergent et d'une forte quantité de sel.
Biemans Ralph
Goraj Carine
Mertens Emmanuel
Vandercammen Anne
Glaxosmithkline Biologicals S.a.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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