C - Chemistry – Metallurgy – 07 – B
Patent
C - Chemistry, Metallurgy
07
B
C07B 59/00 (2006.01) C07B 63/02 (2006.01)
Patent
CA 2720553
The present invention provides novel and advantageous processes for preparing and purifying chemical compounds such as pharmaceuticals. The processes comprise a nucleophilic substitution reaction with a moiety X wherein the leaving group L of a substrate S in the reaction is covalently attached to a purification moiety M. This concept offers a convenient and time-saving way to purify the desired product S-X from non-reacted precursors S-L-M and by-products L-M.
La présente invention concerne de nouveaux processus avantageux pour la préparation et lépuration de composés chimiques tels que des produits pharmaceutiques. Les processus comprennent une réaction de substitution nucléophilique avec un fragment X selon laquelle le groupe partant L dun substrat S dans la réaction est en liaison covalente à un fragment dépuration M. Ce concept offre une technique pratique permettant une économie de temps pour lépuration du produit S-X souhaité à partie de précurseurs S-L-M inaltérés et de produits secondaires L-M.
Berndt Mathias
Chi Dae Yoon
Chu So Young
Cyr John
Graham Keith
Bayer Schering Pharma Aktiengesellschaft
Marks & Clerk
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