C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) C07K 16/42 (2006.01) C12P 21/08 (2006.01) G01N 33/564 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2386393
Disclosed are a preparation comprising Alzheimer's disease antigen (A68), methods of obtaining this purified antigen, and methods of using this purified antigen, for instance, for diagnosing Alzheimer's disease and for detecting human autoantibodies to the Alzheimer disease antigen. The antigen preparation according to the invention is purified in that it is substantially free of immunoglobulin G. The invention further relates to methods of making Alzheimer disease antigens that can be used instead of or along with the A68 antigen preparation (e.g., for diagnosing AD), such as recombinant human tau, tau isolated from various species including human, and phosphorylated recombinant human tau or isolated tau, as well as A68 anti-idiotypic antibodies.
L'invention concerne une préparation contenant un antigène dirigé contre la maladie d'Alzheimer (A68) et des procédés d'utilisation de cet antigène, par exemple, dans le diagnostic de la maladie d'Alzheimer et la détection des auto-anticorps réagissant à l'antigène dirigé contre la maladie d'Alzheimer. On purifie la préparation de l'invention en la libérant sensiblement d'immunoglobuline G. L'invention concerne aussi des procédés de fabrication d'antigènes, dirigés contre la maladie d'Alzheimer et pouvant être utilisés en guise de substitution ou de complément à l'antigène A68 (p.ex., pour diagnostiquer la maladie d'Alzheimer), tels que du tau humain recombinant, du tau isolé à partir de différentes espèces comprenant les humains et du tau humain recombinant isolé ainsi que des anticorps anti-idiotypitques d'A68.
Davies Peter
Debernardis John Francis
Kerkman Daniel Joseph
Kohnken Russel Edwin
Zinkowski Raymond P.
Mbm Intellectual Property Law Llp
Molecular Geriatrics Corporation
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