Purified antithrombin-iii and methods of producing the same

Details Purified antithrombin-iii and methods of producing the same Purified antithrombin-iii and methods of producing the same

C - Chemistry, Metallurgy

07

K

530/15.14

C07K 14/81 (2006.01) A61K 38/57 (2006.01) C07K 1/14 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1341379

Antithrombin-III is purified by contacting an aqueous solution of antithrombin-III derived from human plasma with an insoluble carrier containing as a ligand a hydrophobic group and recovering a non-adsorbed fraction. By this purification, there are provided antithrombin-III preparations containing human plasma- derived antithrombin-III, in which virus is inactivated and which are substantially free from contaminants of at least pyrogen and thermally denatured protein produced by the inactivation.

597405

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