C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/12 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) C12N 11/00 (2006.01) C12Q 1/48 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2149046
2149046 9411007 PCTABS00032 A purified membrane-bound ceramide-activated protein kinase having an apparent molecular weight of about 97 kD as determined by SDS polyacrylamide gel electrophoresis is provided. This protein kinase specifically phosphorylates the threonine residue in a Pro-Leu-Thr-Pro containing polypeptide. A method of determining whether an agent is capable of specifically inhibiting the phosphorylation activity of the ceramide-activated protein kinase is also provided. A method of determining whether an agent is capable of specifically stimulating the phosphorylation activity of the ceramide-activated protein kinase is further provided. A method of treating a subject having an inflammatory disorder is further provided. A method of treating a human subject infected with HIV so as to reduce the proliferation of HIV in the human subject is further provided. Finally, a method of treating a subject having a disorder associated with poor stem cell growth is provided. The figure shows the effect of phospholipases on the ceramide-activate protein kinase catalyzed phosphorylation in the presence of TNF-.alpha..
Golde David W.
Kolesnick Richard N.
Gowling Lafleur Henderson Llp
Sloan Kettering Institute For Cancer Research
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