C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
530/13, 195/1.22
C12N 15/18 (2006.01) A61K 38/18 (2006.01) C07K 1/36 (2006.01) C07K 14/475 (2006.01) C07K 14/48 (2006.01) C07K 16/22 (2006.01) C12N 15/70 (2006.01) C12N 15/85 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2006813
The present invention relates to neurotrophic factors, ciliary neurotrophic factor (CNTF) in particular, as well as methods of purifying CNTF and producing recombinant CNTF. A purified single protein species ciliary neurotrophic factor (CNTF), particularly sciatic nerve ciliary neurotrophic factor (SN-CNTF), having a specific activity increase to greater than 25,000-fold from crude form is produced by recombinant DNA methods including, but not limited to, the steps of acid treatment, chromatofocusing, SDS-PAGE gel and reverse phase-HPLC. Said purification is useful in that it provides probes that facilitate the screening of cDNA and genomic libraries in order to clone genes encoding CNTF. The present invention also provides nucleic acid and corresponding amino acid sequences for CNTF.
Collins Franklin D.
Ko Christine
Lin Leu-Fen
Mismer Drzislav
Regeneron Pharmaceuticals Inc.
Sim & Mcburney
Synergen Inc.
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