C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/475 (2006.01) A61K 38/18 (2006.01) A61K 38/22 (2006.01) C07K 1/26 (2006.01) C07K 17/00 (2006.01) C12N 5/02 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2047718
2047718 9010647 PCTABS00002 The present invention provides highly purified mammalian Ciliary Neurotrophic Factor (CNTF) having a specific activity greater than 2x107 TU/mg protein and a method for obtaining such highly purified CNTF. In addition to having an activity greater than 2x107, highly purified CNTF is characterized by a molecular weight of about 28 kD as determined by SDS-PAGE under either reducing or non-reducing conditions; a PI of about 5.0 to about 5.4; not being inactivated by anti-NGF antibodies; not being inactivated by SDS or reducing agents; and supporting in vitro survival of E8 chick ciliary ganglion neurons, E12 sympathetic ganglion neurons, E10 chick dorsal ganglion neurons and neonatal mouse dorsal root ganglion neurons but not E8 chick dorsal root ganglion neurons; and being sensitive to trypsin and chymotrypsin digestion. The highly purified CNTF may be attached to a solid support, which may in turn be used, for example, to promote the survival of neurons.
Manthorpe Marston
Varon Silvio
Gowling Lafleur Henderson Llp
The Regents Of The University Of California
LandOfFree
Purified ciliary neurotrophic factor does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Purified ciliary neurotrophic factor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Purified ciliary neurotrophic factor will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1845772