Purified compositions of 10-propargyl-10-deazaaminopterin...

Details Purified compositions of 10-propargyl-10-deazaaminopterin... Purified compositions of 10-propargyl-10-deazaaminopterin...

C - Chemistry, Metallurgy

07

D

C07D 475/08 (2006.01) A61K 31/505 (2006.01) A61K 31/519 (2006.01) A61K 31/555 (2006.01) A61K 33/24 (2006.01)

Patent

CA 2260266

Highly purified 10-propargyl-10-deazaaminopterin (10-propargyl-10dAM) compositions tested in xenograft models for their efficacy against human tumors are shown to be far superior to methotrexate ("MTX") and are even superior to the newer clinical candidate edatrexate ("EDX"). Moreover, 10-propragyl-10dAM showed a surprising ability to cure tumors such that there was no evidence of tumor growth several weeks after the cessation of therapy. Thus, highly purified compositions containing 10-propargyl-10dAM can be used to treat human tumors, particularly human mammary tumors and human lung cancer.

Des compositions de 10-propargyl-10-déazaaminoptérine (10-propargyl-10dAM) testées dans des modèles de xénogreffe en ce qui concerne leur efficacité contre les tumeurs humaines se sont avérées très supérieures au méthotréxate (MTX) et même au nouveau candidat clinique: l'édatréxate (EDX). De plus, le 10-propargyl-10dAM a montré une capacité surprenante à traiter les tumeurs telle qu'aucune constatation de croissance d'une tumeur plusieurs semaines après la fin du traitement n'a pu être faite. Les compositions hautement purifiées de 10-propargyl-10dAM peuvent ainsi servir à traiter les tumeurs de l'homme, et en particuliers les tumeurs du sein et le cancer du poumon.

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