C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/209, 260/237
C07D 487/22 (2006.01) A61K 31/40 (2006.01) A61K 41/00 (2006.01) A61N 5/06 (2006.01) C07D 519/00 (2006.01) G02B 6/26 (2006.01) A61B 5/00 (2006.01)
Patent
CA 1271746
ABSTRACT OF THE DISCLOSURE A process for preparing a composition of porphyrin aggreg- ates of greater than 10 kd, which has the capability of localizing in and being retained in tumor cells as compared to normal tissues, wherein the composition is fluorescent and photosensitive, which process comprises dissolving crude hemato- porphyrin derivative in base, adjusting the pH to about 7, and separating the portion of the solute of greater than 10 and from the portion of the solute of less than 10 kd, and recovering the composition consisting essentially of aggregates greater than 10 kd. The compositions obtained by the process are also provided.
436784
Dougherty Thomas J.
Potter William R.
Weishaupt Kenneth R.
Health Research Inc.
Macrae & Co.
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