Purified, highly specific antibodies against gene products...

Details Purified, highly specific antibodies against gene products... Purified, highly specific antibodies against gene products...

C - Chemistry, Metallurgy

07

K

167/139, 167/37,

C07K 16/42 (2006.01) A61K 39/395 (2006.01) C07K 7/04 (2006.01) C07K 14/47 (2006.01) C07K 16/32 (2006.01) C07K 19/00 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2014473

PATENT ABSTRACT A method of identifying epitopes to gene products, specifically the human retinoblastoma (Rb) gene and the corresponding antigenic polypeptides. The amino acid sequence has a combination of low solubility and high hydrophilicity. Highly specific high-affinity anti-Rb- IgGs have been purified using the techniques of this invention. The anti-Rb-IgGs have been used to immuno- precipitate and produce Western Blot patterns associated with normal and abnormal Rb proteins. The method and products of this invention can be used in various diagnostic procedures. APPLN3/BAYA,008

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