Purified igc immunoglobulins

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 1/36 (2006.01) C07K 16/06 (2006.01) C07K 16/28 (2006.01) C12P 21/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2069481

A purified preparation of an anti-CDW52 antibody which exhibits on size exclusion chromatography: a single peak under non-reducing conditions and two major peaks under reducing conditions. The preparation preferably also exhibits on conven- tional SDS PAGE: one main band using a non-reduced sample and two main bands using a reduced sample. Additionally the preparation exhibits on reversed phase HPLC: a single sharp peak under non- reducing conditions and two major peaks under reducing conditions. Also a process of purifying an anti-CDW52 antibody, formulations containing such a purified preparation and uses thereof.

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