C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/64 (2006.01) A61K 38/37 (2006.01) A61K 38/48 (2006.01) C07K 14/755 (2006.01) C07K 16/40 (2006.01) C12P 21/06 (2006.01) C12Q 1/37 (2006.01) G01N 33/573 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2253246
There is disclosed a purified multimerase having an indirect and a direct proteolytic activity, which converts vWF having a singlet structure to vWF having a satellite structure and is active in the presence of the serine protease inhibitor DFP or the calpain protease inhibitor Z-Leu-Leu-Tyr-CHN2, as well as a method of preparing the multimerase according to the invention.
Multimérase purifiée ayant une activité protéolytique indirecte et directe, qui convertit le facteur Willebrand à structure de singlet en facteur Willebrand à structure satellite et qui est active en présence de l'inhibiteur de sérine protéase diisopropyle fluorophosphate (DFP) ou de l'inhibiteur de calpaïne protéase Z-Leu-Leu-Tyr-CHN¿2?, ainsi que procédé de préparation de ladite multimérase.
Eibl Johann
Furlan Miha
Lammle Bernhard
Schwarz Hans-Peter
Turecek Peter
Baxter Innovations Gmbh
Fetherstonhaugh & Co.
Immuno Aktiengesellschaft
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