Purified plasminogen activator, process for its production...

Details Purified plasminogen activator, process for its production... Purified plasminogen activator, process for its production...

C - Chemistry, Metallurgy

12

N

195/127, 167/103

C12N 9/64 (2006.01) C12N 9/72 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1209940

ABSTRACT OF THE DISCLOSURE A plasminogen activator obtained from a tissue cultured liquor of human normal tissue derived cells, e.g., human embryonic derived cells, human placenta derived cells etc., and having the following properties: a) molecular weight measured by gel filtration: 63,000 + 10,000, b) isoelectric point : 7.0 - 8.5, c) affinity to fibrin: present, d) affinity to concanavalin A: present, e) optimum pH. 7 - 9.5, and f) stability : does not lose activity at 60°C for 10 hours but loses about 5% of activity at pH 2-3 at 98°C for a minute; a process for the production of the aforesaid plasminogen activator; and a thrombolytic composition containing the aforesaid plasminogen activator as an active ingredient are disclosed.

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