C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 1/113 (2006.01) A61K 38/30 (2006.01) C07K 1/18 (2006.01) C07K 14/47 (2006.01) C07K 14/65 (2006.01)
Patent
CA 2592014
Complexes of IGF-I and IGFBP-3 with new levels of purity are provided. Chromatographic techniques have been developed that remove contaminants, such as mass and charge variants of IGFBP-3. The new techniques enable the production of high-quality pharmaceutical compositions comprising IGF-I/IGFBP- 3 complexes.
La présente invention concerne des complexes de IGF-I et IGFBP-3 de trois nouveaux niveaux de pureté. L'invention concerne également des techniques chromatographiques d'élimination de contaminants tels que les variantes masse et charge d'IGFBP-3. Ces nouvelles techniques permettent la production de compositions pharmaceutiques de haute qualité comprenant des complexes IGF-I/IGFBP-3.
Kelley Glen L.
Sleevi Mark C.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Insmed Inc.
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