C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 9/127 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) G01N 33/564 (2006.01)
Patent
CA 2258717
The monoclonal antibody (S19), expressed by Deposit HB 12144, ATCC, effectively agglutinates a sperm surface glycoprotein, SAGA-1 protein. The mAB finds utility as a binding agent in a spermicide, showing a high degree of effectiveness in binding potential sperm. The protein bound, identified as SAGA-1, is the immunogen in a contraceptive vaccine, as well as the standard for determining antibody titer upon vaccination. The monoclonal antibody can also be used as a diagnostic to determine the presence, and amount, of sperm in a variety of samples.
L'anticorps monoclonal (S19), objet du dépôt ATCC HB 12144, a pour effet d'agglutiner une glycoprotéine de la surface du sperme, la protéine SAGA-1. Le mAB, qui sert d'agent de fixation dans un spermicide, s'avère très efficace pour fixer le sperme potentiel. La protéine fixée, la SAGA-1, est l'immunogène d'un vaccin contraceptif et sert de référence pour déterminer la concentration en anticorps après vaccination. Ledit anticorps monoclonal peut également servir à des fins diagnostiques pour déterminer la présence et la quantité de sperme dans divers échantillons.
Diekman Alan B.
Herr John C.
Norton Elizabeth
Westbrook-Case Ann
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
The University Of Virginia Patent Foundation
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