G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/534 (2006.01) C07K 1/13 (2006.01) C07K 14/59 (2006.01) G01N 33/564 (2006.01) G01N 33/566 (2006.01) G01N 33/58 (2006.01) G01N 33/74 (2006.01) G01N 33/76 (2006.01)
Patent
CA 2148690
2148690 9409814 PCTABS00032 TSH preparation which is obtained by purification of crude bovine TSH (thyrotropin), can be converted by direct radioiodination into a radioiodinated TSH tracer for a TSH receptor assay, has a biological activity of more than 40 IU TSH/mg protein and is obtainable by purification of commercial crude bovine TSH by affinity chromatography over an anti-TSH antibody column and subsequent ion exchange chromatography over a weakly acidic cation exchanger having terminal carboxyl groups and based on a polyamide-coated silica gel, a corresponding process for its production and its use for the production of a TSH tracer, in particular for a TSH receptor autoantibody assay.
Bergmann Andreas
Struck Joachim
B.r.a.h.m.s. Diagn0stica Gmbh
Osler Hoskin & Harcourt Llp
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