Purified vacuolating toxin from helicobacter pylori and...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/31 (2006.01) A61K 39/02 (2006.01) A61K 39/40 (2006.01) C07H 21/04 (2006.01) C07K 14/205 (2006.01) C07K 16/12 (2006.01) C12P 21/08 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01) G01N 33/574 (2006.01) A61K 31/71 (1990.01)

Patent

CA 2117490

This invention relates to a purified Helicobacter pylori vacuolating toxin and methods to use this toxin to produce protective antibodies against H. pylori infection. Antiserum to this antigen can be used to detect the toxin. Methods to detect anti-toxin antibodies determine the susceptibility of a patient to develop peptic ulcer disease, gastric carcinoma, or other clinical consequences of H. pylori infection.

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