Purine and isosteric antibacterial compounds

Details Purine and isosteric antibacterial compounds Purine and isosteric antibacterial compounds

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A01N 25/24 (2006.01) A61K 31/437 (2006.01) A61K 31/519 (2006.01) A61K 31/522 (2006.01) A61P 31/04 (2006.01) C07D 473/00 (2006.01) C07D 473/18 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2473724

The invention features 2,7-disubstituted purines and their isosteres such as the corresponding 3-deazapurines and 3-deaza-8-azapurines. The compounds disclosed herein have potent anti-microbial, e.g., anti-bacterial and anti- mycoplasmal properties. The compounds described herein inhibit DNA polymerase IIIC and DNA polymerase IIIE species; the compounds thus inhibit the growth of bacteria and mycoplasmata. The compounds can be administered to prevent or to treat Gram-positive or Gram-negative bacterial or mycoplasmal infections, e.g., in eukaryotic cell cultures, animals, or humans.

La présente invention concerne des purines 2,7 substituées et leurs isostères tels que les 3-déazapurines et les 3-déaza-8-azapurines correspondantes. Les composés de cette invention possèdent des propriétés anti-microbiennes puissantes, par exemple des propriétés antibactériennes et anti-mycoplasme. Les composés de cette invention inhibent la polymérase d'ADN IIIC et la polymérase d'ADN IIIE. Ces composés inhibent ainsi la croissance de bactéries et de mycoplasmes. Ces composés peuvent être administrés pour prévenir ou pour traiter des infections bactériennes par Gram positif, par Gram négatif ou par mycoplasme, par exemple dans des cultures de cellules eucaryotes, chez des animaux ou chez des humains.

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