A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/52 (2006.01) A61K 31/505 (2006.01) A61P 19/02 (2006.01) A61P 37/06 (2006.01) A61P 43/00 (2006.01)
Patent
CA 2576159
The present invention relates to the use of an inhibitor of CDK2 and/or CDK7 and/or CDK9, or a pharmaceutically acceptable salt thereof, in the preparation of a medicament for treating a disease associated with antinuclear antibodies, wherein the inhibitor of CDK2 and/or CDK7 and/or CDK9 or pharmaceutically acceptable salt thereof is administered in an amount sufficient to down- regulate the levels of antinuclear antibodies. A further aspect of the invention relates to a combination comprising an inhibitor of CDK2 and/or CDK7 and/or CDK9, or a pharmaceutically acceptable salt thereof, and methylprednisolone, and its use in the treatment of diseases associated with antinuclear antibodies, such as SLE.
L'invention concerne l'utilisation d'un inhibiteur de CDK2 et/ou CDK7 et/ou CDK9, ou un sel pharmaceutiquement acceptable de celui-ci, dans la préparation d'un médicament destiné à traiter une maladie associée aux anticorps antinucléaires; l'inhibiteur de CDK2 et/ou CDK7 et/ou CDK9, où le sel pharmaceutiquement acceptable de celui-ci, étant administré dans des proportions suffisantes pour diminuer le nombre d'anticorps antinucléaires. Dans un autre aspect, l'invention concerne une combinaison qui contient un inhibiteur de CDK2 et/ou CDK7 et/ou CDK9, ou un sel pharmaceutiquement acceptable de celui-ci, ainsi que du méthylprednisolone, et son utilisation dans le traitement de maladies associées aux anticorps antinucléaires, tels que SLE.
Benigni Ariela
Gianella-Borradori Athos
Remuzzi Giuseppe
Zoja Carla
Cyclacel Limited
Gowling Lafleur Henderson Llp
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