Purine base modified 2'-deoxyribonucleosides, use in triplex...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/11 (2006.01) C07F 7/08 (2006.01) C07H 19/04 (2006.01) C07H 19/16 (2006.01) C07H 19/20 (2006.01) C07H 21/00 (2006.01) C07H 23/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2088787

2088787 9221690 PCTABS00017 There are provided purine-base modified guanosine analogues, for example 2'-deoxy, and then ribonucleosides for incorporating into triplex-forming oligonucleotides. Also provided are triplex-forming oligonucleotides for binding into strands of DNA for treatment of disease and regulating genetic expression.

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