C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 473/00 (2006.01) A61K 31/52 (2006.01) A61K 31/535 (2006.01) C07D 239/48 (2006.01) C07D 239/50 (2006.01) C07D 473/06 (2006.01) C07D 473/16 (2006.01) C07D 473/18 (2006.01) C07D 473/28 (2006.01) C07D 473/30 (2006.01) C07D 473/32 (2006.01) C07D 473/34 (2006.01) C07D 473/40 (2006.01)
Patent
CA 2309350
Purine derivatives represented by the following formula and salts thereof: (see formula I) wherein R1 represents a C1-C4 alkyl group or difluoromethyl group; R2 represents tetrahydrofuranyl group, a C1-C7 alkyl group and the like; X represents hydrogen atom, a halogen atom or nitro group; and A represents a group represented by the following formula: (see formula II or III) wherein R3 represents hydrogen atom, a halogen atom and the like; R4 and R5 represent hydrogen atom, a halogen atom, a C1-C4 alkyl group, a C1-C4 alkoxyl group and the like, which are useful as active ingredients of medicaments such as antiasthmatic agents.
Ces dérivés de purine, répondant à la formule générale (I), ou leurs sels se révèlent efficaces comme ingrédient actif de médicaments tels que des antiasthmatiques. Dans cette formule, R<1> représente un alkyle comportant de 1 à 4 atomes de carbone ou un difluorométhyle, R<2> représente un tétrahydrofuranyle, un alkyle comportant de 1 à 7 atomes de carbone, etc., X représente un hydrogène, un halogéno ou un nitro et A représente un groupe répondant à la formule générale (II) ou (III) dans laquelle R<3> représente un hydrogène, un halogéno, etc., R<4> et R<5> représentant chacun un hydrogène, un halogéno, un alkyle comportant de 1 à 4 atomes de carbone, un alcoxy comportant de 1 à 4 atomes de carbone, etc.
Amenomori Akira
Iwashita Eiichirou
Ono Yuya
Tanaka Toshihiko
Tarao Akiko
Dennison Associates
Mitsubishi Chemical Corporation
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