Purine derivatives and pharmaceutically acceptable salts...

Details Purine derivatives and pharmaceutically acceptable salts... Purine derivatives and pharmaceutically acceptable salts...

C - Chemistry, Metallurgy

07

D

C07D 473/28 (2006.01) A61K 31/52 (2006.01)

Patent

CA 2145432

An object of the present invention is to offer novel purine derivatives which exhibit an inhibitory action to nasal mucus secretion and are useful as pharmaceuticals, etc. and pharma- ceutically acceptable salts thereof. The purine derivatives of the present invention are novel compounds which are represented by the following general formula (I). Image (I) [In the formula, R is alkyl or cycloalkyl, or optionally- substituted phenyl or phenylalkyl; R' is hydrogen or -COOX; and X is alkyl, alkenyl, alkoxyalkyl, phenyl or phenylalkyl] The compounds of the present invention are useful as thera- peutic and preventive agents to various types of rhinitis accom- panied by acceleration of nasal mucus secretion and by sneezing reflex such as allergic rhinitis. Moreover, the compounds of the present invention are able to be administered orally and exhibit low toxicity, little side effect and high safety. Accordingly, a continuous administration for long term is possible and they have a very high utility as the drugs.

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