Purine derivatives and suppressants for inflammatory diseases

Details Purine derivatives and suppressants for inflammatory diseases Purine derivatives and suppressants for inflammatory diseases

C - Chemistry, Metallurgy

07

D

C07D 473/30 (2006.01) A61K 31/52 (2006.01)

Patent

CA 2145443

Purine derivatives shown by general formula [1] or pharmacologically acceptable salts thereof. Suppressants for inflammatory diseases containing an effective ingredient of said purine derivative. Image (I) (wherein, R represents one group selected from the groups composed of H atom, a straight chain alkyl group having 1-10 carbon atoms, a branched chain alkyl group having 3-10 carbon atoms, an alkyl group having 1-10 carbon atoms substituted with one carboxyl group, 4-carboxybenzyl group and phenethyl group). Above mentioned purine derivatives prevent the tissue damages due to mediators such as active oxygen and TXA2 in the initial stage of inflammation, and prevent the subsequent aggravation of inflammatory responses due to the adhesion of activated leukocytes to the cells in the lesion, and exhibit efficacy as anti-inflammatory drugs in all stages of inflammatory diseases caused by leukocytes.

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