Purine derivatives and their use as antiproliferative agents

Details Purine derivatives and their use as antiproliferative agents Purine derivatives and their use as antiproliferative agents

C - Chemistry, Metallurgy

07

D

C07D 473/16 (2006.01) A61K 31/52 (2006.01) A61P 35/02 (2006.01)

Patent

CA 2488834

The present invention relates to compounds of formula (1) or pharmaceutically acceptable salts thereof, wherein one of R1 and R2 is methyl, ethyl or isopropyl, and the other is H; R3 and R4 are each independently H, branched or unbranched C1-C6 alkyl, or aryl, and wherein at least one of R3 and R4 is other than H; R5 is a branched or unbranched C1-C5 alkyl group or a C1-C6 cycloalkyl group, each of which may be optionally substituted with one or more OH groups; R6, R7, R8 and R9 are each independently H, halogen, N02, OH, OMe, CN, NH2, COOH, CONH2, or S02NH2. A further aspect of the invention relates to pharmaceutical compositions comprising compounds of formula (1), and the use of said compounds in treating proliferative disorders, viral disorders, CNS disorders, diabetes, stroke, alopecia or neurodegenerative disorders.

L'invention se rapporte à des composés de formule 1 ou à des sels pharmaceutiquement acceptables de ces composés. Dans ladite formule, l'un des R?1 ¿et R?2¿ représente méthyle, éthyle ou isopropyle, et l'autre représente H; R?3¿ et R?4¿ représentent chacun indépendamment H, alkyle ou aryle C¿1?-C¿6?, ramifié ou non ramifié, et dans laquelle au moins l'un des R?3¿ et R?4¿ ne représente pas H; R?5¿ représente un groupe alkyle C¿1?-C¿5? ramifié ou non ramifié ou un groupe cycloalkyle C¿1?-C¿6?, chacun pouvant être éventuellement substitué par un ou plusieurs groupes OH; R?6¿, R?7¿, R?8¿ et R?9¿ représentent chacun indépendamment H, halogène, N0¿2?, OH, OMe, CN, NH¿2?, COOH, CONH¿2?, ou S0¿2?NH¿2?. Dans un autre aspect, l'invention se rapporte à des compositions pharmaceutiques comprenant des composés de formule 1, et à l'utilisation de ces composés dans le traitement de troubles proliférants, de troubles viraux, de troubles du système nerveux central, du diabète, d'un accident vasculaire cérébral, de l'alopécie ou de troubles neurodégénérateurs.

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