Purine derivatives and use thereof in therapy

Details Purine derivatives and use thereof in therapy Purine derivatives and use thereof in therapy

C - Chemistry, Metallurgy

07

D

167/220, 260/242

C07D 473/00 (2006.01) A61K 31/52 (2006.01) A61K 31/675 (2006.01) C07F 9/6561 (2006.01) C07F 9/6571 (2006.01)

Patent

CA 1340909

Antivirally active compounds of the formula (see fig I) wherein: R1 is hydrogen, hydroxy, mercapto or amino; R2 is hydrogen, hydroxy, fluoro, chloro or amino; R3 and R4 are independently selected from (see fig II), amino, hydroxy or an ether or ester residue thereof, or R3 together with R4 is (see fig III) , wherein M is hydrogen or a pharmaceutically acceptable counterion; and n is 1 or 2; with the proviso that, when R2 is amino and R3 and R4 are hydroxy, R1 is not hydroxy and in addition, when n = 1, R1 is not hydrogen, and pharmaceutically acceptable salts thereof; processes for preparation of said compounds, a pharmaceutical composition comprising said compounds, methods for treatment of virus infections as well as use of compounds of the formula I without the proviso for the manufacture of a medicament for treatment of AIDS.

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