Purine derivatives as adenosine a1 receptor agonists and...

C - Chemistry – Metallurgy – 07 – H

Patent

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Details

C07H 19/167 (2006.01) A61K 31/7076 (2006.01)

Patent

CA 2567289

The invention relates to Purine Derivatives, compositions comprising an effective amount of a Purine Derivative; and methods for reducing an animal~s rate of metabolism, protecting an animal~s heart against myocardial damage during cardioplegia; or for treating or preventing a cardiovascular disease, a neurological disorder, an ischemic condition, a reperfusion injury, obesity, or wasting disease, or diabetes, comprising administering an effective amount of a Purine Derivative to an animal in need thereof.

La présente invention se rapporte à des dérivés puriques, à des compositions contenant une dose efficace d'un dérivé purique, et à des méthodes permettant de réduire le taux métabolique d'un animal, de protéger le coeur d'un animal contre l'endommagement du myocarde lors d'une cardioplégie, ou de traiter ou de prévenir des maladies cardio-vasculaires, des troubles neurologiques, des états pathologiques ischémiques, des blessures liées à la reperfusion, l'obésité, la maladie des avortons ou le diabète. Les méthodes selon l'invention consistent à administrer une dose efficace d'un dérivé purique à un animal concerné.

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