Purine derivatives having cyclopropane ring

C - Chemistry – Metallurgy – 07 – D

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C07D 473/40 (2006.01) C07D 239/54 (2006.01) C07D 473/00 (2006.01) C07D 473/18 (2006.01) C07D 473/32 (2006.01)

Patent

CA 2251481

A purine derivative having a cyclopropane ring represented by the formula (I): Image wherein A is -CH2- group or -CO- group; X1 is hydrogen atom, a halogen atom, an alkoxy group having 1 to 10 carbon atoms, or hydroxyl group; each of X2, X3, and X4 is independently hydrogen atom or a halogen atom; R1 is hydrogen atom, a halogen atom, or a protected or unprotected amino group; and each of R2 and R3 is independently hydrogen atom, a substituted or unsubstituted alkyl group having 1 to 7 carbon atoms, a substituted or unsubstituted aralkyl group having 7 to 11 carbon atoms, or a substituted or unsubstituted acyl group having 1 to 7 carbon atoms, with proviso that in a case where A is -CO- group, neither R2 nor R3 is a substituted or unsubstituted acyl group having 1 to 7 carbon atoms, and each of X3 and X4 is independently a halogen atom, and a process for preparing the same.

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