Purine derivatives, process for their preparation and use...

Details Purine derivatives, process for their preparation and use... Purine derivatives, process for their preparation and use...

C - Chemistry, Metallurgy

07

D

C07D 473/34 (2006.01) A61K 31/52 (2006.01) A61P 35/00 (2006.01) C07D 473/16 (2006.01) C07D 473/40 (2006.01)

Patent

CA 2396276

2-, 6-, 8-, 9-monosubstituted, 2,6-, 2,9-, 6,8-, 6,9-disubstituted and 2,6,8-, 2,6,9-, 6,8,9-trisubstituted purine derivatives and their deaza- and aza- analogues with an inhibitor effect with respect to cyclin-dependent kinase proteins (cdks). Their use as anticancer, anti-inflammatory, antiviral, antineurodegenerative, neurodepressive and immunosuppressive compounds.

La présente invention concerne des dérivés de purine 2-, 6-, 8-, 9-monosubstitués, 2,6-, 2,9-, 6,8-, 6,9-disubstitués et 2,6,8-, 2,6,9-, 6,8,9-trisubstitués et leurs analogues déaza et aza, qui possèdent un effet inhibiteur sur les protéines de kinase dépendantes de la cycline (cdks). Elle concerne également leur utilisation en tant que composés anticancéreux, anti-inflammatoires, antiviraux, neurodépresseurs et immunosuppresseurs.

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