Purine derivatives useful as pi3 kinase inhibitors

Details Purine derivatives useful as pi3 kinase inhibitors Purine derivatives useful as pi3 kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 473/34 (2006.01) A61K 31/5377 (2006.01) A61K 31/5383 (2006.01) A61K 31/5386 (2006.01) A61K 31/541 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2703138

This invention provides a compound which is a purine of formula (Ia) or (lb): and the pharmaceutically acceptable salts thereof that are inhibitors of PI3K and a selective for the p1 10.delta. isoform, which is a class la PI3 kinase, over other class la PI3 kinases and over class lb kinases. The compounds may be used to treat diseases and disorders arisi from abnormal cell growth, func- tion or behaviour associated with PI3 kinase such as cance immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine function disorders and neurological disorders.

L'invention porte sur un composé qui est une purine de formule (Ia) ou (Ib) : et sur les sels pharmaceutiquement acceptables de celui-ci qui sont des inhibiteurs de PI3K et sélectifs pour l'isoforme p110d, qui est une PI3 kinase de classe Ia, par rapport à une autre PI3 kinase de classe Ia et par rapport aux kinases de classe Ib. Les composés peuvent être utilisés pour traiter des maladies et des troubles provenant d'une croissance, d'une fonction ou d'un comportement cellulaires anormaux associés à la PI3 kinase tels que le cancer, des troubles immunitaires, une maladie cardiovasculaire, une infection virale, une inflammation, des troubles du métabolisme/de la fonction endocrinienne et des troubles neurologiques.

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