Purine inhibitor of protein kinases, g proteins and polymerases

Details Purine inhibitor of protein kinases, g proteins and polymerases Purine inhibitor of protein kinases, g proteins and polymerases

C - Chemistry, Metallurgy

07

D

C07D 473/16 (2006.01) A61K 31/52 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2297967

The present invention relates to purine analogs having general formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4 and R5 are independently members selected from the group consisting of H, C1-C8 straight- chain, branched-chain, saturated and unsaturated alkyl, C1-C8 straight-chain, branched-chain, saturated and unsaturated substituted alkyl, aryl and substituted aryl, that inhibit, inter alia, protein kinases, G-proteins and polymerases. In addition, the present invention relates to methods of using such purine analogs to inhibit protein kinases, G-proteins, polymerases and other cellular processes and to treat cellular proliferative diseases.

L'invention concerne des analogues de purine représentés par la formule (I) ou un de leurs sels acceptables sur le plan pharmaceutique, dans laquelle R?1¿, R?2¿, R?3¿, R?4¿ et R?5¿ sont des éléments indépendants sélectionnés dans le groupe constitué par H, alkyle C¿1?-C¿8? à chaîne linéaire ou ramifiée, saturé ou insaturé, alkyle C¿1?-C¿8? substitué à chaîne linéaire ou ramifiée, saturé ou insaturé, aryle et aryle substitué. Ces analogues inhibent, entre autres, des protéines kinases, des protéines G et des polymérases. Elle concerne, de plus, des procédés servant à utiliser ces analogues de purine afin d'inhiber des protéine kinases, des protéines G, des polymérases et d'autres processus cellulaires, ainsi qu'à traiter des maladies de prolifération cellulaires.

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