Purine l-nucleosides, analogs and uses thereof

Details Purine l-nucleosides, analogs and uses thereof Purine l-nucleosides, analogs and uses thereof

C - Chemistry, Metallurgy

07

H

C07H 15/20 (2006.01) A61K 31/52 (2006.01) A61K 31/522 (2006.01) A61K 31/70 (2006.01) A61K 31/7056 (2006.01) A61K 31/7076 (2006.01) A61K 31/7115 (2006.01) A61K 45/06 (2006.01) C07H 19/00 (2006.01) C07H 19/02 (2006.01) C07H 19/04 (2006.01) C07H 19/056 (2006.01) C07H 19/06 (2006.01) C07H 19/14 (2006.01) C07H 19/16 (2006.01) C07H 19/20 (2006.01)

Patent

CA 2266889

Novel purine L-nucleoside compounds are disclosed, in which both the purine rings and the sugar are either modified, functionalized or both. The novel compounds or pharmaceutically acceptable esters or salts thereof may be used in pharmaceutical compositions, and such compositions may be used to treat an infection, and infestation, a neoplasm, or an autoimmune disease. The novel compounds may also be used to modulate aspects of the immune system, including modulation of Th1 and Th2.

L'invention concerne des composés de nucléosides L purine nouveaux, dans lesquels les noyaux puriques et le sucre sont modifiés, fonctionnalisés ou modifiés et fonctionnalisés. Ces composés nouveaux ou leurs esters ou leurs sels pharmaceutiquement acceptables peuvent être utilisés dans des compositions pharmaceutiques, ces compositions pouvant être utilisées pour traiter une infection, une infestation, un néoplasme ou une maladie auto-immunitaire. Ces composés nouveaux peuvent également être utilisés pour moduler des aspects du système immunitaire, dont une modulation de Th1 et de Th2.

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