C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/7028 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) C07D 405/04 (2006.01)
Patent
CA 2751458
The present invention is directed to compounds, compositions and methods for treating or preventing cancer and viral infections, in particular, HIV, HCV, Norovirus, Saporo virus, HSV-1, HSV- 2, Dengue virus, Yellow fever, and HBV in human patients or other animal hosts. The compounds are certain 6-substituted purine monophosphates, and pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof. In particular, the compounds show potent antiviral activity against HIV-1, HIV-2, HCV, Norovirus, Saporovirus, HSV-1, HSV-2, Dengue virus, Yellow fever, and HBV.
La présente invention concerne des composés, des compositions et des méthodes permettant de traiter ou de prévenir le cancer et les infections virales, en particulier le VIH, le VHC, les norovirus, le virus de Sapporo, le VHS de type 1, le VHS de type 2, le virus de la dengue, la fièvre jaune, et le VHB chez les patients humains ou autres hôtes animaux. Les composés sont certaines purines monophosphates substituées en 6, et leurs sels, promédicaments, et autres dérivés pharmaceutiquement acceptables. En particulier, les composés présentent une activité antivirale puissante contre VIH-I, VIH-2, VHC, les norovirus, le virus de Saporo, VHS de type 1, VHS de type 2, le virus de la dengue, la fièvre jaune et VHB.
Cho Jong Hyun
Coats Steven J.
Schinazi Raymond F.
Zhang Hongwang
Zhou Longhu
Emory University
Rfs Pharma Llc.
Ridout & Maybee Llp
LandOfFree
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