A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/43 (2006.01) A61K 39/21 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2734147
A process for inhibiting a mammalian cancerous cell or virally infected cell includes providing a Trichomonas vaginalis purine nucleoside phosphorylase enzyme or a tail mutant purine nucleoside phosphorylase enzyme in proximity to the mammalian cancerous cell or the virally infected cell and exposing the enzyme to a purine nucleoside phosphorylase enzyme cleavable substrate to yield a cytotoxic purine analog. The process includes introducing to the cell a vector containing the phosphorylase enzyme, or a DNA sequence coding for the same and delivering to the cell an effective amount of the substrate such as 9-(.beta.-D-arabino- furanosyl)-2- fluoroadenine (F-araA).
L'invention concerne un procédé pour inhiber une cellule cancéreuse de mammifère ou une cellule infectée par virus, comprenant la fourniture d'une enzyme purine nucléoside phosphorylase de Trichomonas vaginalis ou d'une enzyme purine nucléoside phosphorylase mutante de queue à proximité de la cellule cancéreuse de mammifère ou de la cellule infectée par un virus, et l'exposition de l'enzyme à un substrat pouvant être clivée par l'enzyme purine nucléoside phosphorylase, afin de produire un analogue de purine cytotoxique. Le procédé comprend l'introduction dans la cellule d'un vecteur contenant l'enzyme phosphorylase, ou d'une séquence d'ADN codant pour celle-ci, et la délivrance à la cellule d'une quantité efficace du substrat, comme 9-(ß-D-arabinofuranosyl)-2-fluoroadénine (F-araA).
Parker William B.
Sorscher Eric J.
Ridout & Maybee Llp
Southern Research Institute
The Uab Research Foundation
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