C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 473/32 (2006.01) A61K 31/52 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2721851
Purine compounds of Formula I, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
La présente invention concerne des composés puriniques de formule I, et comprenant des stéréoisomères, des isomères géométriques, des tautomères, des solvates, des métabolites et des sels pharmaceutiquement acceptables de ceux-ci. Lesdits composés sont utiles pour inhiber les kinases des lipides comprenant la p110 alpha et d'autres isoformes de la PI3K, et pour traiter des troubles tels que le cancer induit par les kinases des lipides. Linvention concerne également des procédés dutilisation des composés de formule I pour le diagnostic in vitro, in situ, et in vivo, la prévention ou le traitement de tels troubles dans les cellules de mammifères, ou des conditions pathologiques associées.
Castanedo Georgette
Chuckowree Irina
Folkes Adrian
Sutherlin Daniel P.
Wan Nan Chi
F. Hoffmann-La Roche Ag
Genentech Inc.
Smart & Biggar
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