C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/00 (2006.01) C07H 19/06 (2006.01) C07H 19/10 (2006.01) C07H 19/16 (2006.01) C07H 19/20 (2006.01)
Patent
CA 2334610
Compounds are described comprising purines substituted at the C-8 position and pyrimidines substituted at the C-4 or C-5 position with a linker and quencher. These compounds when incorporated into hairpin oligonucleotides quench the fluorescence of fluorophores linked to the 5'-terminus of the oligonucleotide. These nucleotide-quencher compounds are also easy to incorporate into oligonucleotides using conventional, automated, oligonucleotide synthetic techniques.
L'invention concerne des composés contenant des purines substituées en position C-8 et des pyrimidines substituées en position C-4 ou C-5 par une séquence de liaison et un extincteur de fluorescence. Ces composés, quand on les incorpore dans des oligonucléotides en épingle à cheveux, éteignent la fluorescence de fluorophores liés à la terminaison 5' de l'oligonucléotide. Ces composés d'extinction de fluorescence de nucléotides sont également faciles à incorporer dans des oligonucléotides au moyen de techniques classiques automatisées de synthèse d'oligonucléotides.
Boal Jila
Nardone Glenn
Nazarenko Irena
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Intergen Company
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