Purinone antianginal agents

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 473/30 (2006.01) A61K 31/52 (2006.01) A61K 31/535 (2006.01) C07D 473/00 (2006.01)

Patent

CA 2139109

Compounds of formula (I), and pharmaceutically acceptable salts thereof, wherein R1 is C1-C4 alkyl; R is C2-C4 alkyl; R3 is H or SO2NR4R5; R4 and R5 together with the nitrogen atom to which they are attached form a pyrrolidino, piperidino, morpholino or 4-N-(R6)-1-piperazinyl group; and R6 is H or C1-C3 alkyl; are selective cGMP PDE inhibitors useful in the treatment of, inter alia, cardiovascular disorders such as angina, hypertension, heart failure and atherosclerosis.

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