Purposeful movement of human migratory cells away from an...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 14/52 (2006.01) A61K 38/19 (2006.01) A61K 39/395 (2006.01) A61P 29/00 (2006.01) C07K 14/81 (2006.01) C07K 16/24 (2006.01) C12P 21/00 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2367173

This invention relates to methods and compositions for modulating movement of eukaryotic cells with migratory capcity. More specifically, the invention relates to methods and compositions for modulating movement of cells of hematopoietic, neural, epithelial, or mesenchymal origin, in a specific site in a subject. The foregoing are useful, inter alia, in the treatment of conditions characterized by a need to modulate migratory-cell movement associated with specific site in a subject. More specifically, specific sites include sites of inflammation and modulation of migratory-cell movement is movement away from an agent source, or repulsion. Other sites include tumor sites, sites of pathogenic infection, and germ cell bearing sites.

La présente invention concerne des procédés et des compositions destinés à moduler le mouvement de cellules eucaryotes ayant une capacité migratoire. Plus particulièrement, l'invention concerne des procédés et des compositions destinés à moduler le mouvement de cellules d'origine hématopoïétique, neuronale, épithéliale ou mésenchymateuse dans un site spécifique chez un sujet. Lesdits procédés et compositions sont utiles, inter alia, pour le traitement d'affections caractérisées par la nécessité de moduler le mouvement de cellules migratoires associé à des sites spécifiques chez un sujet. Plus particulièrement, des sites spécifiques incluent des sites d'inflammation, et un mouvement de cellules migratoires est un mouvement qui s'éloigne d'une source d'agents ou un mouvement de répulsion. D'autres sites incluent des sites de tumeur, des sites d'infection pathogène, et des sites d'accueil de cellules germinales.

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