A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) A61K 38/45 (2006.01) A61K 39/395 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C12Q 1/48 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2436266
The present invention relates to the use of a HER2 protein or a nucleic acid coding therefor as a target for the modulation of the mitogen-activated protein (MAP) kinase pathway. Further, the use of a PYK2 protein and a nucleic acid coding therefor as a target for the modulation of the MAP kinase pathway is described. By inhibiting HER3 kinase activity, the phosphorylation of PYK2 and thus the stimulation of the MAP kinase pathway is inhibited. The present invention is preferably suitable for applications, particularly diagnostic or medical applications, wherein an inhibition of the MAP kinase pathway is desired. Thus, the invention relates to novel methods for diagnosing, treating or preventing MAP kinase associated disorders such as tumors.
L'invention concerne l'utilisation d'une protéine HER2 ou d'un acide nucléique la codant tenant lieu de cible pour la modulation de la voie de la kinase MAP (protéine kinase activée par des mitogènes). L'invention concerne en outre l'utilisation d'une protéine PYK2 et d'un acide nucléique la codant tenant lieu de cible pour la modulation de la voie de la kinase MAP. L'inhibition de l'activité de la kinase HER3 entraîne l'inhibition de la phosphorylation de PYK2 ainsi que la stimulation de la voie de la kinase MAP. L'invention se prête, de préférence, à des applications diagnostique ou médicale lorsque l'on souhaite inhiber la voie de la kinase MAP. L'invention concerne, par conséquent, de nouvelles méthodes de diagnostic, de traitement ou de prévention des troubles associés à la kinase MAP, notamment les tumeurs.
Ullrich Axel
Van Der Horst Edward Htun
Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.v.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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